Potential risks Serious risks and adverse events include: Allergic reaction to the medications or dye used in the injection Shoulder infection Depigmentation of the skin around the injection site (a whitening of the skin) Local fat atrophy around the injection site (thinning of the skin) Rupture of a tendon located in the path of the injection Nerve damage near the shoulder joint Bleeding at the injection site In addition to the above, corticosteroid injections increase the risk of: High blood pressure High blood sugar Decreased immune function Decrease in bone mineral density Bone infection (osteonecrosis) Reproductive hormone imbalance Metabolic changes (eg, increased appetite, weight gain, and fluid retention) These risks are typically associated with higher doses of corticosteroids, multiple injections, and for people with underlying medical conditions such as diabetes and heart problems
Research in the Soviet Union and Eastern Europe, where DSIP was more extensively studied than in Western countries, reported positive findings for sleep disorders, stress adaptation, and various other conditions, though methodological limitations and lack of independent replication limited the impact of this work
Many payers have specific policies for compounded GLP-1 medications that may limit coverage
Instead, it delivers a spectrum of signaling molecules that activate TrkB, TrkA, and CNTF receptor pathways simultaneously
Unlike other B12 forms, methylcobalamin is directly used by the body without requiring additional conversion
